Tom Curry, a winger, will not play for England against Wales on Saturday in Cardiff after once again pulling out due to injury.
Curry, who was absent from England’s opening two Six Nations matches due to a leg injury, is replaced in the 26-man squad by his twin brother Ben.
Fly-half George Ford, who was only recalled to the England team on Sunday, is not included in the squad.
Cadan Murley, a wing, is still active and might make his international debut soon.
Murley was able to join the team because Ollie Hassell-Collins, the starting wing, had already been ruled out of Saturday’s game due to a knee injury.
After a string of injuries, former captain Courtney Lawes has resumed full training and might make his first England appearance since July.
Lawes has been sidelined due to neck, glute, and calf problems as well as a concussion, but England defensive coach Kevin Sinfield told BBC Sport that “he is ready to go” against Wales.
Lawes enters a crowded pack where Ben Earl, a replacement against Scotland and Italy, cannot fit because of competition.
Veteran scrum-half Ben Youngs is once again passed over in favor of Alex Mitchell and Jack van Poortvliet.
Tom Curry’s unidentified leg injury, according to Sinfield, is not “serious,” and the flanker will undergo additional testing to identify the issue.
“We believe the game will proceed,”
England’s first Six Nations match under new head coach Steve Borthwick ended in a loss to Scotland before a victory against Italy.
Wales lost both of their initial contests, which has raised some questions about Saturday’s match because players are threatening to strike over a contract dispute with Welsh rugby executives.
Owen Farrell, the captain of England, stated that his team has been practicing as usual and added: “We do believe that the game will proceed.
“The players are obviously not pleased with what is occurring in their camp, which is why they are acting in the manner that they are.
“Hopefully everything works itself out for everyone, and the game on Saturday will be wonderful.”
Chessum, Cole, B Curry, Dombrandt, Genge, George, Isiekwe, Itoje, Lawes, Ludlam, Sinckler, M Vunipola, Walker, and Willis make up the forwards on the England team.
Backs: Watson, Arundell, Marchant, Mitchell, Murley, Slade, Farrell, Lawrence, Malins, Marchant, Smith, Steward, Van Poortvliet, and Mitchell.