After Pierre-Emile Hojbjerg done an outstanding job of finding Kane inside the area, the England captain surpassed the milestone with a cool finish from 10 yards out.
Fans sprang from their seats to clap for the 29-year-old striker, who scored his first goal for Spurs on December 15, 2011, when a message reading “Congratulations Harry Kane” lit up on the scoreboard inside the stadium.
Kane scored his 200th goal in the Premier League in the 15th minute; only Wayne Rooney (208) and Alan Shearer (260 goals) have scored more.
It happened unexpectedly and while Tottenham manager Antonio Conte was recuperating at home following gallbladder surgery.
In the absence of their Italian manager, Tottenham, who finished the game with 10 men after defender Cristian Romero received two cautions in the 87th minute, battled hard to frustrate City.
After Arsenal’s setback at Everton on Saturday, Pep Guardiola’s team wasted the opportunity to reduce Arsenal’s five-point advantage at the top of the standings.
Riyad Mahrez came the closest to tying the score with a shot that ricocheted off the underside of the bar, but City have failed to pick up a point or score in their last five trips to the Tottenham Hotspur Stadium.
Tottenham’s victory takes them one point below fourth-place Newcastle even though they are still five points behind Arsenal despite having played one more game.
Observations following Tottenham’s Kane’s historic goal vs Man City
Kane overtakes Greaves as the top scorer in Spurs history.
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a message thanking Harry Kane on setting the club’s all-time scoring record was displayed on the scoreboard at Tottenham Hotspur Stadium.
On April 7, 2014, Harry Kane scored his first Premier League goal as part of Tottenham’s 5-1 victory over Sunderland.
a suitable environment for a memorable moment
Kane, who was 18 when he scored his first goal for Spurs against Shamrock Rovers in the Europa League 12 years ago, celebrated his historic goal with all the vigor of a young man.
It seemed appropriate that it occurred at the Tottenham Hotspur Stadium in front of his team’s supporters, who erupted into a raucous cheer after the ball sailed past City goalkeeper Ederson.
Greaves scored 266 goals after 379 games, compared to Kane’s 267 goals in 416 games.
The only letdown was that his manager Conte was not in the stadium to see the goal.
After his procedure, the Italian was absent, and Cristian Stellini, his assistant, took over against City.
Following the final whistle, Kane’s teammates and the Tottenham coaching staff remained on the field as the forward enjoyed the moment while being interviewed there.
On the huge screen, Danny Greaves’ statement thanking the player on his incredible achievement was then played for Kane to hear.
Outstanding Royal keeps Spurs competing for a top-four spot.
This was the teams’ second Premier League encounter in 17 days after Manchester City rallied from a 2-0 deficit to defeat the other team 4-2 at Etihad Stadium on January 19.
This time, Spurs resisted City’s attempts to retake the lead in a fiercely fought game, with Emerson Royal providing some excellent challenges.
Rodri’s attempt was stopped by Hugo Lloris, while Eric Dier diverted Julian Alvarez’s goal-bound shot aside.
The hosts had opportunities to increase their advantage in this exciting game, but Ben Davies’ goal-bound attempt went just over and Ederson’s save on Kane’s second attempt.
Spurs marked one of their best performances of the season with a significant victory that leaves them very much in the running to finish in the top four, and the final whistle was greeted by yet another thunderous scream.
A day to forget for the City and Haaland
For City, which has now dropped their previous three league and cup games away from home, this was a day to forget.
Kevin de Bruyne and Ilkay Gundogan were both started by Guardiola, and Phil Foden was not present due to a nighttime illness.
Erling Haaland had a rare off day as Kane grabbed all the attention.
The striker, who dominated the Premier League in his first season in England with 25 goals, managed just 27 touches and no shots.
Next Sunday against Aston Villa at home, City will try to rebound before an exciting top-of-the-table matchup against Arsenal on February 15. (19:30 GMT).